In modern pharmacology it's so clear that even if you have a fixed dose of a drug, the individuals respond very differently to one and the same dose.

Well, in pharmacology, if the effect is local, it's of course absolutely awkward to use it in any other way than as a local treatment.

Thinking is movement confined to the brain

Fluorine has a protecting action against caries, but this is a local effect. If you drink it, you are running the risk of all kinds of toxic actions.

He was a consummate politician-- which is to say he was given to expedient speech and lacked even a vestigial spine.

Leadership is a longterm game.

It's not that we fly by the seat of our pants. We're not afraid of failure.

To some extent, Seattle remains a frontier metropolis, a place where people can experiment with their lives, and change and grow and make things happen.

Think before you speak, and don't say everything you think.

After a disappointing summer, Humpty Dumpty has a great fall.

The Constitution: it's not just a good idea, it's the law.

Creed's sound is my sound.

I didn't know whether I'd be attractive to anybody.

In this world of chance and change and mutability, the fulfillment of any resolve depends on the will of the Lord.