If my work has a theme, I suspect it is a simple one: that most human beings are inescapably alone, and therein lies their tragedy.

It's a disease. Nobody thinks or feels or cares any more; nobody gets excited or believes in anything except their own comfortable little God damn mediocrity.

if you don’t try at anything, you can’t fail… it takes back bone to lead the life you want

And do you know a funny thing? I'm almost fifty years old and I've never understood anything in my whole life.

Why did everything always change when all you wanted, all you had ever humbly asked of whatever God there might be, was that certain things be allowed to stay the same?

if you wanted to do something absolutely honest, something true, it always turned out to be a thing that had to be done alone.

He couldn't even tell whether he was angry or contrite, whether it was forgiveness he wanted or the power to forgive.

Do you know what the definition of insane is? Yes. It’s the inability to relate to another human being. It’s the inability to love.

No one forgets the truth; they just get better at lying.

You're painfully alive in a drugged and dying culture.

Never say anything that doesn't improve on silence.

Death is not the end! The exit for the world of mortals is the entrance to the world of immortals!

Our perceptions shape whether challenges are obstacles that block our path to success or important arrows that steer us in the direction we want to go.

I feel like 'Amelie' is very much an extension of me. She's a contemporary woman who sees the world through her imagination.

Christian humility does not consist in denying what there is of good in us; but in an abiding sense of ill-desert, and in the consciousness that what we have of good is due to the grace of God.

Humanity is exalted not because we are so far above other living creatures, but because knowing them well elevates the very concept of life.

When I was 8 years old, I knew what I was going to be—an actress.

What we have lived through, the 20th century, has been like a great party. Adults now have had the best time humanity has ever had. Now the party is over and the Earth is reckoning up.

I remember being mad about having pink and red shoes. I gew up envying other girls' pink and red shoes.

I go out and look for a good story to tell and if I like it enough and I decide to direct it, I become dangerously involved in becoming a part of that story.

Science is defined in various ways, but today it is generally restricted to something which is experimental, which is repeatable, which can be predicted, and which is falsifiable.