An ultimate joint challenge for the biological and the computational sciences is the understanding of the mechanisms of the human brain, and its relationship with the human mind.

Here is a language so far ahead of its time, that it was not only an improvement on its predecessors, but also on nearly all its successors.

I call it my billion-dollar mistake. It was the invention of the null reference in 1965.

The unavoidable price of reliability is simplicity.

The real value of tests is not that they detect bugs in the code but that they detect inadequacies in the methods, concentration, and skills of those who design and produce the code.

Some problems are better evaded than solved.

Inside every large program is a small program struggling to get out.

I don't know what the language of the year 2000 will look like, but I know it will be called Fortran.

Premature optimization is the root of all evil in programming.

The price of reliability is the pursuit of the utmost simplicity. It is a price which the very rich may find hard to pay.

You cannot teach beginners top-down programming, because they don't know which end is up.

Hughes might discuss Calvinism ably, but he did not live it, he was—by Time corporate standards—just a little lazy.

Everyone needs a place to be honest.

A woman's life can really be a succession of lives each revolving around some emotionally compelling situation or challenge and each marked off by some intense experience.

Being frozen into the passive position of an object whose very existence depends on the eye of its beholder turn the educated modern Western women into a harem slave.

I don't think that it is necessary to rethink curricular goals. But it is certainly worth thinking about whether these goals can be reached in multiple ways.

Each of us has capacities. The real trick is knowing the machinery of the boat in which you are crossing the channel.

Acting in "Star Wars," I felt like a raisin in a giant fruit salad, and I didn't even know who the cantaloupes were.

Anywhere I see suffering, that is where I want to be, doing what I can.

Let the other fellow get the headlines. I'll take the laws.

If thou dost marry, I'll give thee this plague for thy dowry: be thou as chaste as ice, as pure as snow, thou shalt not escape calumny.